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And let us not forget, good old fashioned investment in research and development either through the federal government or through innovative public-private partnerships can be a significant driver of downstream innovation and commercialization.
Mr Bhidé argues that this downstream innovation, which is far more complex and customised than the original upstream invention, is the most valuable kind and what America is best at.
The current issues with commercialisation output indicators call for other indicators that would better reflect the downstream innovation process taking place in the firms to provide a more complete picture of public science impact on the industry.
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Downstream innovations include (1) disposable devices for clarification and purification, (2) improved resins and ligands, and (3) new designs of hardware for improved performance.
They enable downstream innovations in products, processes, business models and business organization (Satapathy and Mishra 2013).
"Each upstream patent allows its owner to set up another tollbooth on the road to product development, adding to the cost and slowing the pace of downstream biomedical innovation".[ 23] The emerging patent thicket represents a distinct threat to the traditions of open science required for progress.
This required spending on key areas both upstream and downstream of the innovation chain, with some of the most innovative companies, including Tesla, receiving early stage high-risk finance and loans from public agencies.
Advances in separation technology for capturing antibodies from complex feedstocks have been one focus of downstream purification process innovation for past 10 years.
In most cases, these clusters are anchored by either world-class research universities or large-scale national labs which provide critical talent and conduct the basic science and engineering that often fuel downstream, more applied innovation.
Bioprocess R&D at Sanofi Pasteur is focused upon manufacturing process to provide material for clinical trial experimentation, with upstream, downstream, and formulation innovations.
Previous literature finds that larger downstream markets fuel the innovation of new technologies by incentivizing firms to spend more on R&D.
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