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For example, the mouse Q10 gene contains a 13 bp deletion in the exon encoding the Tm domain, causing a frame shift and the introduction of a premature termination signal downstream in the same exon.
The HP motif is present in 34 43 residues from phosphorylatable aspartate, and a protein kinase-like GxGxxG/A motif is found downstream in the same domain.
For example, genetic variation can perturb the expression of a gene, which then can affect the activity of other genes downstream in the same pathway.
Gene 1 extended only with the disruption of the functional stop codon and if another stop codon was present downstream in the same frame.
Interestingly, the deletion of 9.4 kb in NG14 in the scaffold 1 was missing in the Illumina sequencing data and instead a deletion of 1 kb was identified about 7 kb downstream in the same scaffold in NG14 [ 9].
In the case where an MTU is located downstream, in the same orientation, a TSS is classified as an sTSS only if the distance between start codon and TSS exceeds the pmTSS threshold of 300 nt.
Similar(51)
Many enzymes involved in a reaction at a particular branch point are also involved in other downstream reactions in the same, and/or different branches.
In-frame deletions that removed more than 90% of the coding sequence and were designed to not interfere with expression of downstream genes in the same operon were constructed in these and other genes involved in LPS biosynthesis.
In the case of nov13, TBLASTN identified high scoring hits in both P. fluorescens SBW25 and Pf-5, but in both cases a stop codon was absent, which would result in a fusion with the downstream gene in the same reading frame.
It is located directly downstream and in the same orientation as highly induced ddrA (Deide_09150).
It could be that the smaller-effect loci shared between populations represent downstream genes in the same or related pathways that serve to fine-tune control of SAM size and function.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com