Sentence examples for downstream in the process from inspiring English sources

We found MCU interacts with VDAC1 and functions as the downstream in the process of oxidative stress-induced cell death.

As the substrate or the web traverses downstream in the process flow, proper registration of the pre-existing features is necessary prior to entering the next fabrication zone in order to accurately complement previous manufacturing steps.

Certainly, targeting an EWS/FLI1 mediator which is more upstream, such as GLI1, could be expected to have more extensive effects than targeting a gene further downstream in the process.

Our results for activated RET and signal transduction molecules in human melanoma cells (Figures 4 9) partially correspond to our previous reports of increased activation and protein expression levels of RET and signal transduction molecules sited downstream in the process of melanomagenesis in RET-mice [10], [18].

These proteins work together with their associated sigma factor (σE and σG, respectively) to modulate transcription of genes downstream in the process.

While the pathogenesis of AD involves the extraneuronal deposition of the amyloid-beta peptide and phosphorylation of intraneuronal tau proteins [ 2], loss of synapses is thought to play an important downstream role in the process of cognitive loss [ 3, 4].

Vacuolization was also effectively suppressed by structurally unrelated calpain inhibitors, suggesting that these Ca2+-dependent proteases are downstream effectors in the process of Ca2+-induced formation of endocytic vacuoles.

A recent report suggests that the binding of the antigens with the receptors on the T, B or mast cells induces a series of biochemical reactions leading to a transient increase in cytosolic free calcium concentration that leads to other downstream reactions in the process of allergic response [ 56].

This set of routines helped prevent quality problems by avoiding the passing of defects downstream in the assembly process, without stopping production.

Altogether, these findings indicate that Daam1a and Ulk2 play a synergistic role in the promotion of neuropil growth, and that Daam1a is likely to work downstream of Ulk2 in the process.

One of these target genes is HAT3, which has been shown to play an important role downstream of REV in the process of setting up polarity in the young leaf primordium (Bou-Torrent et al., 2012; Brandt et al., 2012; Turchi et al., 2013).