Sentence examples for downstream event from inspiring English sources

As expected, uttroside B induced cleavage of PARP, a downstream event of caspase activation.

MLKL translocation as a downstream event of RIP3 was required in matrine-induced necroptosis.

These data together indicated that MLKL translocation to plasma membrane, as a downstream event of RIP3, was critical for matrine to induce necroptosis.

Together, these results suggest that proteolytic activation of PKCδ may be a critical downstream event in the degenerative process of Parkinson's disease.

Translocation of mixed lineage kinase-domain like (MLKL) from cytoplasm to plasma membrane as a downstream event of RIP3, as well as the increased production of reactive oxygen species (ROS) by RIP3/MLKL, was critical for matrine to induce necroptosis.

Additionally, we showed that ATRA inhibited NRF2 activation as a downstream event of ALDH1 suppression and in particular, we demonstrated that the effect of ATRA on ALDH1A1-NRF2 axis was restricted to ALDH1-high cells.

Down-regulation of Cacnb3 expression did not rescue placental hyperplasia in a model of interspecies hybrid placentas, which indicates that up-regulation in the hyperplastic placentas is a downstream event.

Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway.

The activation of EGFR by TLR ligands is generally believed to be a downstream event of TLR-ligand interaction.

The results indicated that 4-oxo-4-HPR caused induction of ER stress response, as downstream event of ROS generation.

To confirm that TNFα induces apoptosis via type II pathway we investigated another downstream event of mitochondria activation which is cytochrome c release to the cytosol.