Sentence examples for downstream elements of the from inspiring English sources

Aberrant activation of the EGFR pathway in CRC could be caused by either EGFR overexpression or mutational activation of downstream elements of the EGFR pathway [7].

To evaluate whether these dimorphisms were autonomous to corazonin neurons, as opposed to dimorphic downstream elements of the circuitry, we introduced the transformer element, which feminizes male cells [28], to corazonin neurons.

It is plausible that the CFPAC-1 cell line, which was refractory to all of these treatments, carries an activating mutation in downstream elements of the Wnt signaling pathway that would bypass the need for extracellular Wnt ligands and the Sulfs.

The role of Lrp4 as an antagonist of canonical Wnt signaling pathway is thought to be mediated in part by a displacement of the homologous Lrp5/6 proteins in the co-receptor complex formed by frizzled proteins (fzd) with Lrp5/6, which is required to bind Wnt proteins and to transduce the Wnt signal to downstream elements of the canonical cascade.

The clinical significance of this effect by the drug on the downstream elements of the VHL/HIF pathway is under investigation.

These studies demonstrate the power of comparative whole genome transcriptional profiling for identifying specific downstream elements of the DR life span extending pathway.

Two further studies have characterized downstream elements of this pathway.

Heterogeneous nuclear ribonucleoprotein 1 (HRP1) may be a marker protein that binds to the downstream element of the nonsense mutation and interacts with NMD factors [12].

Yki is the key effector of growth control and the downstream element of the highly conserved Hpo (Hippo) signaling pathway.

The mRNA levels of AMBRA1, an important BECN1 cofactor, were also higher in HIV-1-infected patients; by contrast, the level of ATG5, a downstream element of the autophagic program, was not significantly modified in PBMC from HIV-infected individuals when compared with those from noninfected controls (data not shown).

It blocks common downstream elements of both the mitochondrial pathway and the death receptor pathway, by directly inhibiting terminal effector caspase-3, caspase-7, and caspase-9 activity[ 1, 2].