Sentence examples for downstream element of the from inspiring English sources
Heterogeneous nuclear ribonucleoprotein 1 (HRP1) may be a marker protein that binds to the downstream element of the nonsense mutation and interacts with NMD factors [12].
Yki is the key effector of growth control and the downstream element of the highly conserved Hpo (Hippo) signaling pathway.
The mRNA levels of AMBRA1, an important BECN1 cofactor, were also higher in HIV-1-infected patients; by contrast, the level of ATG5, a downstream element of the autophagic program, was not significantly modified in PBMC from HIV-infected individuals when compared with those from noninfected controls (data not shown).
Aberrant activation of the EGFR pathway in CRC could be caused by either EGFR overexpression or mutational activation of downstream elements of the EGFR pathway [7].
To evaluate whether these dimorphisms were autonomous to corazonin neurons, as opposed to dimorphic downstream elements of the circuitry, we introduced the transformer element, which feminizes male cells [28], to corazonin neurons.
The role of Lrp4 as an antagonist of canonical Wnt signaling pathway is thought to be mediated in part by a displacement of the homologous Lrp5/6 proteins in the co-receptor complex formed by frizzled proteins (fzd) with Lrp5/6, which is required to bind Wnt proteins and to transduce the Wnt signal to downstream elements of the canonical cascade.
It is plausible that the CFPAC-1 cell line, which was refractory to all of these treatments, carries an activating mutation in downstream elements of the Wnt signaling pathway that would bypass the need for extracellular Wnt ligands and the Sulfs.
These downstream elements of the mTOR signaling cascade are deregulated in the brain of Alzheimer's disease patients well before the development of pathology.
These studies demonstrate the power of comparative whole genome transcriptional profiling for identifying specific downstream elements of the DR life span extending pathway.
The higher levels of expression of downstream genes might facilitate the amplification of signals through their progression throughout signaling cascades, which requires higher protein abundances for the downstream elements of the pathway (e.g., ref. [ 38]).
