Sentence examples for downstream early from inspiring English sources

The transient transfection of miR-K12-7 into 293/Bac36 cells reduced RTA expression and the expression of the downstream early genes regulated by RTA, and also the production of progeny virus was significantly reduced after treatment with chemical inducers.

We also demonstrated that miR-K12-7-5p miR-K12-7-5p miR-K12-7-5p miR-K12-7-5p downslightlyareduceses regulathe by RTA (PAN, ORF57, and ORF59) at 48 h post chexpressionuctiof (Figure 4A) and significanthe redownstreamproduction of progearlyirus in the 293/Bac36 cell line (Figenes4C), which is latently infected with KSHV, upon chemical induction.

A downstream marker (early response, late response or cell adhesion, etc).

Downstream of early receptor signalling, IL-2 is produced and used by T cells in an autocrine fashion in response to stimulation to drive proliferation [7].

It further seems to be involved in hippocampal activation of the transcription factor cAMP response element binding protein (Creb1) and downstream immediate early genes [ 62].

Hct116 cells are deficient in mismatch repair and consequently contain point and insertion/deletion mutations scattered throughout the genome, some of which may limit the activity of the virus downstream of early viral promoter activation.

They also showed that GRO β and its downstream product early growth response protein (EGR1) were associated with cisplatin-induced apoptosis in a human esophageal squamous cell carcinoma cell line [ 24].

Therefore, methoxychlor may exert its action not directly at the site of progesterone action, but downstream on early events in maturational signaling, although the precise mechanism of action is unclear.

Our findings in a much simpler experimental system are consistent with this mechanism and suggest that it acts downstream of early fusion stages at a stage of fusion pore expansion.

The interaction of Eomesdermin with Smad2 may be a general mechanism downstream of early Nodal signalling in vertebrates since in Xenopus Eomesdermin has been shown also to interact physically with Smad2 [ 18].

At the top of the genetic cascade of cortical interneuron development are the transcription factors DLX1 and DLX2 which are activated in all interneurons downstream of early patterning genes (Table 1 and Figure 2).