Sentence examples for downstream defect from inspiring English sources

Interestingly, the levels of FANCD2 and its monoubiquitinated form were not affected in these patients, suggesting a downstream defect in the FA pathway.

This may occur through various mechanisms, including an increase in proteasomal degradation, defects in post-translational modification, and downstream defects in p53 target genes.

The lack of closure of the circulatory loop may explain some downstream defects described in this phenotype such as the lack of a correct lumen formation.

The lack of closure of the circulatory loop has never been described before and may explain some downstream defects of the phenotype such as the lack of a correct vascular remodeling.

This may be related to downstream defects in the p53-dependent intrinsic apoptosis pathway (Hougardy et al, 2005).

Therefore, it is possible that downstream defects, notably in the signalling and execution of apoptosis, are majorly responsible for melanoma drug resistance.

It is easy to speculate that reduced Smn levels may disrupt the production or assembly for rRNA and lead to downstream defects in ribosomal function.

However, excluding, Δ msgA, the remaining six NPP mutants showed no significant decline in trehalose level during germination in CA. Therefore, it would appear that these six NPP mutants mobilized conidial trehalose stores to fuel germination on glucose, but downstream defects in saccharide metabolism impeded successful germination.

This suggests compensatory LT-HSC expansion due to downstream differentiation defects.

This finding is in keeping with the increased frequency of LT-HSCs observed in Lsd1fl/fl micere mice and suggests compensatory LT-HSC expansion due to downstream differentiation defects.

Our results reveal, for the first time, in vivo efficacy and safety of a molecular therapy that improves downstream metabolic defects in TK2 deficiency.