Sentence examples for downstream changes in the from inspiring English sources

Furthermore, neither study reported brachial artery blood flow data after PM exposure, which would provide some insight into downstream changes in the resistance vasculature.

The integration of GWAS data with studies that examine the downstream changes in the RNA, protein and metabolite state has the potential to reveal the perturbations in molecular networks that are associated with disease.

A common feature in genetical genomics studies of expression traits is the presence of eQTL hotspots where a single polymorphism leads to widespread downstream changes in the expression of distant genes.

The significance of the order of events leading from heparan sulfate accumulation through to downstream changes in the levels of biomolecules within the cell and ultimately the (predominantly neuropathological) clinical symptoms is not well understood.

A single polymorphism leads to widespread downstream changes in the expression of distant genes by affecting major regulators or transcription factors (TFs), which would be visible as an eQTL hotspot and can lead to large and consistent biological effects.

One of the central concepts in genetical genomics is the existence of QTL hotspots, where a single polymorphism leads to widespread downstream changes in the expression of distant genes, which are all mapping to the same genomic locus [ 37].

The loss of striatal dopamine innervation in PD produces opposing downstream changes in firing of the two main basal ganglia motor pathways by virtue of their distinct dopamine receptor populations (Smith et al., 1998; Blandini et al., 2000; Figure 1).

This observation raises the issue of a possible interconnection between DNA damage response and likely downstream changes in cell shape and/or motility, the finding that deserves to be addressed more specifically in future.

In this study we describe the targeted knockdown of 11 genes using siRNA in BMDMs and the downstream changes in gene expression caused by specific siRNA activity as measured using genome-wide, exon-level microarrays (for list of genes targeted see Table 1).

We focused not on the causative lesions per se but on the myriad downstream changes in gene expression associated with domestication.

However, these lesion studies are potentially confounded by demyelination of fibres passing through the lesion site, and the possibility of secondary, downstream changes in associated brain structures as a consequence of their chronic denervation following the lesion.