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This network represents a (bio chemical manifestation of downstream changes in shape, form, growth and development.
The Holocene succession displays consistent downstream changes in facies architecture: well-drained floodplain deposits are transitional at distal locations to increasingly organic, poorly drained floodplain to swamp facies associations.
This very early process controls downstream changes in cell proliferation, regeneration-specific gene expression, and axonal patterning, and is both necessary and sufficient for regeneration of spinal cord, muscle, and vasculature in the tail.
These results appeared to be highly vitronectin-dependent since uPAR-vitronectin interaction is well-known to be sufficient to initiate downstream changes in cell migration and signal transduction [34].
We questioned therefore whether expression of GFP-lamin A in SW480 cells caused downstream changes in T-plastin expression and whether T-plastin might be implicated in the increased invasiveness observed here.
Recent application of molecular genetics to this field has confirmed the crucial role of bioelectric signals in regenerative processes, identified the ion transporters responsible for generating instructive ion flows, and characterized downstream changes in gene expression.
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Furthermore, it is also possible that any behavioural effects of the lesion could reflect a secondary, downstream change in an associated brain structure as a consequence of the chronic denervation of that structure following the lesion [15].
Other downstream changes, such as reduction in dermal fibrosis, with increased dermal microcirculation and early regression of the extent of CT scan fibrosis in systemic sclerosis were reported.
Mutations or polymorphisms are then selected for upstream regulators of the network, resulting in numerous downstream changes.
We reasoned that, should antisense transcription be a consequence of active transcription of the downstream gene, changes in antisense transcript level across the IDC should be positively correlated to those of the downstream mRNA.
Glasscock says, "we're leveraging the fact that RNA expression is downstream of changes in DNA.
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CEO of Professional Science Editing for Scientists @ prosciediting.com