Sentence examples for downstream as a consequence from inspiring English sources

Activation of members of the signal transduction and activator of transcription (STAT) family, in particular STAT3, was revealed downstream as a consequence of the binding of IL-11 to its corresponding receptor [12].

Subsequently, an interaction of this complex with an exon junction complex (EJC), deposited downstream as a consequence of the splicing process, leads to the formation of the decay-inducing complex (DECID) that results in mRNA degradation [ 8].

· Evidence of downstream pharmacodynamic effects as a consequence of target engagement.

L1 insertions are often accompanied by 3' transduction, the co-mobilization of DNA sequences downstream of an L1 as a consequence of transcriptional read-through resulting from a weak L1 poly(A) signal [ 24- 27].

Integrated water resources management (IWRM) approach looks at the whole urban water cycle and across the urban rural continuum at environmental consequences downstream, as well as socioeconomic benefits of resource recovery.

As a consequence, downstream synthesis of extracellular matrix proteins, such as fibronectin, elastin and collagen, is reduced [ 16, 17].

Hence, this could potentially serve as a mechanism by which α-syn perturbs downstream effects of PLCβ as a consequence of reduced activation of lipid signaling pathways.

Such therapeutics would, in principle, target either the pathogenic trigger, the expanded-CGG-repeat mRNA itself ("toxic RNA"), or downstream pathways that are altered as a consequence of the abnormal FMR1 mRNA expression.

While some mRNAs are directly refractory to SOX, the steady state levels of others remain unchanged, presumably as a consequence of downstream effects on mRNA biogenesis.

Cdk activation occurs downstream of death signal initiation and as a consequence of degradation or caspase-mediated cleavage of negative regulators of cdks.

As a consequence, the downstream target genes of TGF-β relevant to growth response, such as p21, p15 and Cyclin D1, are deregulated, which will lead to cell senescence and inhibition of cell growth in COUP-TFII deficient mice.