Sentence examples for downstream alternative from inspiring English sources

These results clarify which internal exon encodes the ErbB4 JM-b isoform, and demonstrate that the ErbB4 JM-b isoform is not encoded by exon 15, which is constitutive, but is instead encoded by a downstream alternative exon E15b, located between the exons 15 and 16 (Figure 3A).

Upstream or downstream alternative primers were designed and tested in cases where gel bands were ambiguous.

We observed that intragenic transcriptional enhancers, upon activation or silencing, affect the activity of downstream alternative transcription start sites.

However, TCGA methylation profiles showed that only the downstream alternative promoter region becomes hypermethylated in breast cancers.

We see differences between unique and alternative promoters, between 5' promoters (UP or FAP) and downstream promoters, and between first alternative and more downstream alternative promoters.

Our systematic investigation of Drosophila promoters demonstrates that there are distinct sequence characteristics among unique, first alternative, and downstream alternative promoters, suggesting that different regulatory mechanisms may act preferentially on each class.

In contrast, no correlation is seen when editing occurs downstream of alternative splicing [ 35].

In both cases, a specific transcript is likely to be obtained from the initiation or termination of transcription downstream of alternative promoters and polyadenylation sites, respectively.

Frequently, activation of signalling pathways downstream or alternative to EGFR may be responsible for the development of resistance to these inhibitors (Sansal and Sellers, 2004).

Besides direct VEGF or VEGFR2 inhibition for glioblastoma, clinical studies are being conducted or planned with agents targeting further downstream or alternative pathways frequently altered in brain tumors, including the mTOR/Akt and EGFR pathways [ 39].

These results illustrated that the cooperative inhibition of Ba/F3 cells' proliferation and clonigenicity is not mediated by the Bcr-Abl protein, and that probably the two kinase inhibitors target downstream or alternative signaling pathways that control the growth of these cells.