Sentence examples similar to downstream age from inspiring English sources

Another possible mechanism may be that reducing insulin/IGF-1 signaling leads to down-regulation of certain downstream aging-promoting signaling pathways.

This leads to a decreased expression of the elt-3 GATA transcription factor in old age that causes down-regulation of many downstream age-regulated genes.

In wild-type animals, DAF-16 is normally maintained in the cytoplasm by inhibitory phosphorylation from the IIS-activated AKT kinases that are activated downstream of AGE-1 and PDK-1 (Fig. 1A).

What's more, the number of high-risk dams keeps rising as structures age, downstream development increases and more accurate information is obtained about watersheds and earthquake hazards.

Thus, the strata in the Yangtze drainage basin tend to increase in age downstream.

CTGF and CYR61 are downstream effectors of AGE in the diabetic retina, implicating them as possible targets for future intervention strategies against the development of diabetic retinopathy.

These findings illustrate an evolutionary conserved epigenetic mechanism that determines the rate of aging downstream of mitochondrial perturbations.

We reviewed the role of OS and its downstream signaling in aging eyes.

This provides the first evidence that CTGF and CYR61 are downstream effectors of AGEs in the diabetic retina and implicates them as possible targets for future intervention strategies.

Sck2p is a putative member of S6 kinases, which play conserved roles in translational regulation and cellular ageing downstream of TORC1 (Laplante and Sabatini, 2012).

We see the clear downstream consequences during aging emerging in the proteome, including metabolic shifts, stoichiometric loss, aggregating proteins, and protein overproduction.