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Discover LudwigThe word 'downregulation' is correct and usable in written English.
You can use it to refer to a decrease in the amount of expression of a gene, hormone, or protein. Example sentence: To treat this disorder, medical professionals employ downregulation of the gene in question.
Dictionary
downregulation
noun
The process, in the regulation of gene expression, in which the number, or activity of receptors decreases in order to decrease sensitivity
Exact(1)
Failing to use these for long periods means cells can undergo a process known as downregulation, where they produce less of certain proteins.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com