Sentence examples for downregulated activity from inspiring English sources

Structure-activity relationship studies and binding mode hypotheses were used to optimize the scaffold and yield the compound BMD4503-2, which recovered the downregulated activity of the Wnt/β-catenin signaling pathway by competitive binding to the LRP5/6-sclerostin complex.

We did not measure serum levels of progesterone in C. ocellatus and thus cannot determine whether the downregulated activity of PGR corresponds to a lower concentration of the hormone during late pregnancy or whether PGR downregulation is a mechanism of functional progesterone withdrawal.

In our study, tunicamycin downregulated Wnt activity, while siCHOP inverted downregulation of Wnt induced by tunicamycin.

Interestingly, CK2-Is downregulated SIRT1 activity and over-expression of SIRT1 decreased p53 transcriptional activity and rescued cells from CK2-I-induced apoptosis.

An NO donor, sodium nitroprusside (SNP), downregulated GATA activity and GATA-4 mRNA expression.

However, a downregulated Rom2 activity would jeopardize its function for cell wall repairing or remodeling at cell periphery, leading to cell lysis defect under stress conditions.

Coincident with the downregulated luciferase activity of the positive control miRNA, SV40-miR-s1, all of the SGIV miRNAs that passed the validation of stem-loop quantitative RT-PCR were able to suppress the luciferase activity (>25 50%) (Fig. 7B).

In both lines bortezomib transcriptionally downregulated telomerase activity by inhibiting hTERT expression.

It was also discovered that HIF-2αA/B downregulated luciferase activity under hypoxic conditions.

These results prove that the effects of downregulated mTORC2 activity on mTORC1 are indeed mediated via the TSC2-involving cascade.

In addition, this finding shows that the effects of downregulated mTORC2 activity on mTORC1 are indeed mediated via the TSC2-involving cascade.