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"down with the flu" is a correct and usable phrase in written English.
You could use it to describe someone who has caught the flu virus and who is feeling unwell because of it. For example: My sister has been down with the flu for the past week, so she won't be able to make it to the party.
Exact(56)
Jimmy comes down with the flu.
Then I came down with the flu.
Perhaps he is down with the flu.
The third, Valerie Holiday, was down with the flu.
Sadly, Ms. Voigt came down with the flu.
Several days later the mother came down with the flu, and she died shortly thereafter.
In case anybody went down with the flu or something, they could put me in there.
He assumed he'd come down with the flu his family had just had.
WHEN the British economy catches a cold, Scotland often goes down with the flu.
Sykora came down with the flu today in Chicago, so both were scratched.
Though none of Ms. Bacchi's siblings came down with the flu, her uncle fell sick.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com