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If we consider the flux profiles shown in Fig. 4A, we see that the introduction of a statin-like inhibitor steps down the flux at the interaction HCoA-M and that this has consequences for many of the interactions downstream of HCoA-M.
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This would slow down the autophagic flux, cause accumulation of aberrant protein intermediates and would have a later effect on apoptosis.
"For a start, a few muons still make it down here though the flux is less than a millionth that it is on the ground.
Red color corresponds to up-regulation in both flux and in transcription, and blue corresponds to down-regulation both on the flux level and on the transcriptional level.
Thus, thermal dynamos essentially are either on or off, controlled by the flux of heating down the adiabatic gradient to the surface of the core from its interior.
Accordingly, average CO2 diffusing flux to the atmosphere from the river had been reduced by three-fourth from the 1960s to 1990s, with the flux value being down to 14.2 mol.m-2.yr-1 in the 1990s.
Production of K metabolites is achieved normally by the flux of Trp down the hepatic pathway, but can be increased if TDO activity is enhanced.
Production of K metabolites is achieved by the flux of Trp down the KP, without the need for induction of any particular enzyme, as long as the enzymes are functionally expressed.
Mitochondrial membrane potential and ROS production are dependent on the flux of electrons down the electron transport chain (ETC), which in turn are dependent on the production of electron donors (NADH, FADH2) from the Krebs' cycle.
A statin-like intervention leads to a step down in flux towards the start of the pathway with the result that the flux passing through many of the interactions in the upper half of the pathway is significantly lower than the levels observed in immune-led responses.
More NADPH was generated with the flux of GAPDN increased, which would result in a decrease flux of GAPDH to down-regulate NADH production.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com