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The dubious clinical meaning and doubtful existence of normal breast-like subtype, also reflected in its heterogeneous clinical presentations of ER and HER2 phenotypes, remained unsolved and demanded further evaluations.
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After her death in 1881, Seacole's fame declined and her memoirs were not reprinted again until 1984, when two researchers, doubtful of its existence, rediscovered it in the British Library catalogue.
Sir Mark Walport said a section of the general public was increasingly doubtful about the existence of climate change and mankind's responsibility for it in the face of the global economic downturn, sceptical media coverage and "climate fatigue".
Sir Mark Walport said a section of the general public was increasingly doubtful about the existence of climate change and human responsibility for it in the face of the global economic downturn, sceptical media coverage and "climate fatigue", he told The Independent.
Without the business, without a job, my husband seems a bit doubtful of his existence.
Some health care workers (49.3%) were doubtful about the existence of specific processes to manage changes in policies, programmes and infrastructure for performance, 40.6% agreed and 10.1% disagreed.
Whether the self-styled Bundesliga-Dino (dinosaur) can soon return to a more comfortable existence is doubtful, while the situation off the pitch remains as fraught with vagaries as Johan Djourou's thought-process.
Although Boleslaus the Brave's notched sword has not been preserved and even its very existence is doubtful, its legend had a great impact on Polish historical memory and the treatment of its successor, the modern Szczerbiec.
While a part of us wants to believe that all those years of wearing a purity ring have led Jonas to some very kinky proclivities, unless the tape surfaces for all to see, its existence does seem doubtful -- despite Blind Gossip's very detailed account of the alleged tape.
Conversely, the existence of RAI is doubtful when baseline (free) cortisol levels are high or when 250 μg ACTH is regarded as a supraphysiologic stimulus [ 5, 18, 24].
It is doubtful whether it ever had any real existence.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com