However, recent studies have cast doubt on the specificity of these symptoms for schizophrenia, suggesting alternative outcomes such as anxiety and depression.
One of the main reasons for this no doubt is the specificity of each screening platform (e.g. plates format, automatic collection of results), which requires more specific developments to collect the results and associate them with tested molecules.
Although CSA-binding properties have been mapped to several VAR2CSA domains using in vitro binding assays [13], [33], [34], recent published data [35], [36] casts doubt on the specificity of single DBL domains for CSA.
The endogenous production of hydroxyl radicals by PMNs is in doubt because the specificity of the experiments has been questioned, and it has been argued that exogenous iron in the buffers used during in vitro experiments could catalyze the production of hydroxyl radicals rather than endogenous production in PMNs [31].
Controversially, both studies [ 48, 53] using MS-MLPA reported methylation of BRCA2 in a sizeable number of tumors, and this casts doubt on the specificity of this methodology.
In 1989, PSA expression was first discovered [ 5] through immunohistochemical reactions in some apocrine foci of female fibrocystic breast tissue as well as in breast cancer (BC), casting doubt on the specificity of this kallikrein only for prostatic epithelium.
Using this experimental design we highlight the contribution of the parietal cortex (bilaterally) to inhibitory processes, while casting doubts about the specificity of frontal activation in such processes.
Concerning the latter study [13], the uniform immunofluorescence throughout the cell casts doubts on the specificity of the antibody used.
Our data contrasts recent EEG studies casting doubts on the specificity of the cortical responses following single or repeated laser stimuli activating the cutaneous Aδ fibers [46], [47].
These results are in disagreement with several studies reporting HA specific IE cytoadhesion [13], [14], [24], [29], [30], but supported by other studies that raised doubts on the specificity of HA mediated IE cytoadhesion [22], [23], [31].
