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The extension of the two-carbon chain of mescaline by alpha-methylation to the three carbon chain of TMA approximately doubled the potency of the compound.
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Designated booster load zones along the track replenish the meter, and a super boost power-up is available which doubles the potency of the boost.
The 2-pyridyl compound 16 (IC50=33 n m) doubles the potency when compared with the sulfide linker analogue 13, whereas 4-pyridyl derivative 18 (IC50=15 n m) displays a fourfold increase in inhibitory activity and is one of the most potent compounds in this series.
In comparison with their sulfide linker analogues, compounds 30, 31 and 33 all exhibit nearly double the potency.
Ever use of any combined hormone replacement therapy decreased the risk, whereas ever use of low- or high-potency oestrogen only doubled the risk.
Compared to an average of 50-80 mg of MDMA contained in pressed pills throughout the dawn of the 90s raving scene, the current average dose in a pressed pill of ecstasy has increased to double that potency at 125 mg.
A recent report from the European Monitoring Centre for Drugs and Drug Addiction found that compared to an average of 50-80 mg of MDMA contained in pressed pills throughout the 1990s and 2000s, the current average dose in a pressed pill of ecstasy has increased to double that potency: 125 mg.
For SH-SY5Y cells, concomitant exposure to 500 nM LY379196 led to approximately a doubling of the potency of doxorubicin, paclitaxel, and vincristine.
Doubling the dose was similar in effect size to doubling potency (i.e., halving EC50) in this simulated example.
This is in direct contradiction to the DEA's own figures on marijuana potency which find that today's average cannabis seizure may have doubled in THC potency (a 100% increase, not a 3,000% increase).
Introduction of a cyano-substituent on 10 to give the 2-methyl-5-cyano analogue (12) resulted in reduced ClogP together with doubled potency and increased selectivity over FFA4.
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