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The COX proportional hazard model demonstrated that doubled expressions of three genes, i.e., CREB5, PTPRB and COL4A3, was associated with 63% to 97% decreased risk of death, recurrence or progression, suggesting their potential role as tumor suppressors (Table 6).
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Here where only Piétrains are female, we observed a doubled expression of the USP9X and no expression of USP9Y.
In these tissues, doubling expression (i.e. increasing by one log2 unit) was associated with approx. 0.01 fewer N atoms per amino acid residue.
Surprisingly, stable transduction of control cells with COG4 (thereby doubling expression levels) resulted in a retrograde trafficking defect, reminiscent of that observed in patient cells.
(a) The first could be referred to as the cosine synchronisation degree (SDa1) since it is estimated as a vectorial angle between time series of I-O coefficients in their double expressions: SDa 1 = ∑ t ( a ij, t ∗ ca ij, t ) / [ ( ∑ t a ij, t 2 ) 1 / 2 ( ∑ t ca ij, t 2 ) 1 / 2 ] (6).
A phosphate transporter gene (id 20658) was highly expressed throughout the garden and doubled its expression level in the middle and bottom sections relative to the top.
The males showed the highest expression levels of p62 at P90 and, in case of p62 protein, the males even doubled the expression levels of females (*** p < 0.001).
The knockdown in our hands was efficacious in that the sponge doubled the expression of the inverse reporter, but it did not restore the inverse reporter to the levels seen in cells lacking miR-132.
Incubation with DAA at 50 ng/ml DAA and 5 μg/ml doubled mRNA expression significantly at 24 hours (p < 0.05) but not at 6 hours.
Treatment with 100 μM AgNO3 raised the PUN1 mRNA about 3-fold whereas 50 μM HgCl2 and 10 μM CdCl2 doubled the expression relative to control cells (Fig. 1, left panel).
Our data clearly demonstrate that TGFβ3 wildtype palates from E15.5 expressed increased TGFβ3 protein, double the expression of heterozygous and as expected the homozygous palates were completely devoid of any TGFβ3 expression (Additional file 1).
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