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The distinct tubulin and α-synuclein binding motives of TPPP/p25 were also demonstrated at the cellular level: the double truncated TPPP/p25 did not align along the microtubules in contrast to the full length form, while it induced α-synuclein aggregation.
The combinatory expression of both deleted genes LdTopΔL/ΔS, served to generate a double truncated protein from EKY3 yeast deficient strain.
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In the first-stage, bias-corrected Data Envelopment Analysis (DEA) efficiency estimates for the individual MFI are obtained by means of the smoothed homogeneous bootstrapped procedure (Simar and Wilson, 2000) and then they are regressed on a set of explanatory variables employing the double bootstrap truncated regression approach (Simar and Wilson, 2007).
He has doubled or truncated his sinks to resemble tombstones, chests or awkwardly joined torsos.
This reconstructed double-truncated frequency distribution could be considered as a reliable segment of the empirical specific binding avidity distribution.
When only the tail of the GDP is available for analysis, the double-truncated GDP function (13) where (14) could be used for quantification of empirical distributions.
By analogy to (32), it is easy straight forward to derive the double-truncated K-W function for any low threshold value t (t = 1, 2,...) of the number of TFs bound to a given TFBS, and next using the re-normalized K-W function, to estimate parameters of the double-truncated K-W function using the optimization algorithm reported in [ 20].
Because of the lower force distribution of final single peaks, the iLOV unfolding force distribution is truncated compared to final double peak force traces, supporting the notion that the binding mode is set prior to mechanical loading of the complex.
The crash on Mont Ventoux provided the most memorable image of the race, Froome on foot running up the mountain, but it stemmed from a failure of organisation: not enough barriers to contain a crowd that had doubled after the stage had been truncated due to high winds.
When forecasts > 300 μg/m were truncated to 300 μg/m (approximately double the highest Monitor PM2.5 concentration), the point estimates were larger and the CIs were wider than those calculated with the original data (Table 2).
We examined the independence of N- and C-terminal anion regulatory regions by studying a double mutant in which the N terminus was truncated at AA 139 and the C terminus truncated at AA 1665.
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