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It is necessary to double the hazard ratio to 5.4 to increase the average C-index of the perfect discrimination model to 0.68.
In comparison to ambulatory patients, bedridden patients had double the hazard to die or develop TB [aHR = 2.47; 95 % CI (1.62, 3.75)], and working patients had a 33%% lower hazard to die or develop TB [aHR = 0.67; 95 % CI (0.50, 0.89)].
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Hyponatremia in non-ACLF patients nearly doubled the risk (hazard ratio (HR) 1.81 (1.33 to 2.47)) of dying at 90 days.
Findings from the Cox regression analyses indicated that, compared with risperidone, patients treated with haloperidol had double the risk of mortality (hazard ratio adjusted for propensity score 2.07, 95% confidence interval 1.89 to 2.26) and patients treated with quetiapine had a reduced risk (0.81, 0.75 to 0.88).
In effect, the commission could look at two markets - the national market and the tabloid middle market - doubling the hazards to a deal.
19– 23 In a study of American Indian children, extreme BMI (the highest quartile compared with the lowest quartile) doubled the hazards of premature death.
These effect estimates were followed in magnitude by a group of risk factors which were associated with somewhat less than double the mortality hazard.
In patients who were prescribed these drugs, there was an estimated overall statistically significant doubling of the hazard of death (hazard ratio 2.08), after adjusting for a wide range of potential confounders, including physical and psychiatric comorbidities, sleep disorders, and other drugs.
Meanwhile, the power calculations suggested that the number of cohort members with lower than mean birth weight in each of the analyses summarised in Table 1 (n = 425) was sufficient to detect just under a doubling of the hazard for CVD (or a HR of 1.92) at 90% power and a significance level of 0.05.
Although this tree would produce lumber, cutting the tree would include the double hazard of the stem under tension and the likely re-settling of the root ball.
33 We found no evidence for this in our data; on the contrary, more than one prison episode almost doubled the overall hazard of death and decreased the probability of achieving long term cessation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com