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65 min: Double substitution for Sporting.
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None of the simulations yielded a greater number of double-nucleotide substitutions than were observed in the cancer genomes, hence p < 0.001 for the observed enrichment of double substitutions for each cancer genome.
To determine whether the S162A and Q266I substitutions were effective in all natural hSTING variants, we generated the respective single and double substitutions for all major hSTING alleles (listed in Figure 3D) and tested them for DMXAA recognition.
Spurs were on the rack and the change in momentum prompted a double substitution from Pochettino, Kane and Townsend brought on for Nabil Bentaleb and Chadli.
Cue a double substitution, with Ezequiel Lavezzi on for Agüero and Rodrigo Palacio for Higuaín.
73 min: Poland respond by making a double substitution, Mierzejewski and Brozek on for Obraniak and Murawski.
But the veteran manager must take credit for a double substitution shortly after the break that changed the game.
But the Canaries - who had won seven of their previous eight home league games - are a different proposition under Lambert, and the Scot settled for a double substitution to rouse his side.
Pellegrini immediately sent on Navas for Aguero and it was not long before Poyet made a double substitution, bringing on Fletcher and Craig Gardner for Johnson and Seb Larsson.
Dalglish used Liverpool's numerical advantage to make a double substitution, sending on Suarez and Meireles for Carroll and Dirk Kuyt.
This double substitution caused complete loss of activity for peptide 22 (data not shown).
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