Sentence examples for double minute from inspiring English sources
Murine double minute 2. Positron emission tomography.
Murine double minute 2 (Mdm2) inhibitors enhance apoptosis in tumours harbouring wild-type p53.
It is inactivated by mutation or binding with human double minute 2 (HDM2) protein.
The murine double minute 2 (MDM2) gene encodes a negative regulator of the tumor protein p53.
It has also been shown to interact with the human murine double minute 2 (MDM2) and control its activity [24].
Iron status influences p53 activity and antioxidant response by modulating the expression of MDM2 (mouse double minute gene 2) (Dongiovanni et al., 2010).
We have recently discovered a specific Murine Double Minute 2 (MDM2) oncogene inhibitor, called SP141, which exerts potent anticancer activity in various breast cancer models.
Peptidic Mouse Double Minute (MDM2) inhibitors have been demonstrated to effectively inhibit the interaction between p53 and MDM2, thus providing a therapeutic strategy for some tumors.
They were designed to interact with the proteins elongation initiation factor 4E (eIF4E) and mouse double minute 2 (MDM2) and were then validated by competitive fluorescence anisotropy experiments.
In almost 50% human tumor cells, however, the p53 protein is dysregulated by direct interaction with its negative regulator, the Murine Double Minute 2 (MDM2) protein.
PURPOSE: Increased murine double minute 2 (MDM2) expression, independent of p53 status, is associated with increased cancer-specific mortality for men with prostate cancer treated with radiotherapy.
