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It may be relevant that a study in Mexico City reported a double incidence peak for AL, at 2 3 and 6 9 years of age (Bernaldez-Rios et al, 2008).
Although more than half of the tumors with CEP17 gain were not HER2 or TOP2A amplified, we did observe a higher than double incidence of CEP17 gain in tumors with aberrant HER2 and TOP2A genes (amplification, deletion, and, especially, high copy gains) in comparison to tumors with a normal status of these genes.
Similarly, Hass et al. (2009) detected significantly more abnormal pretreatment TSH levels (TSH > 3.0 mU/L or <0.4 mU/L) in female patients and Testa et al. (2006) reported almost double incidence of hypothyroidism in female as compared to male patients [ 32, 33].
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A 1995 report from Saudi Arabia found a doubled incidence at 7 cases per 100,000; this was attributed to the fact that Behçet's disease, which increases risk of CVST, is more common in the Middle East.
To conclude, we found a doubled incidence of patients admitted with BM during the 20-year long study period.
Fibroids are hormone-sensitive tumours, and so it is perhaps not surprising that use of HT doubles incidence rates in postmenopausal women.
Screening for prostate cancer in the United States has caused an almost doubling incidence, whereas mortality has remained relatively stable (McDavid et al, 2004).
Another USRDS study which looked at subdural hematoma (ICD 432.1) showed a doubling incidence from 1991 to 2002 in the hemodialysis cohort but no significant upward trend for those on peritoneal dialysis [ 33].
Alcohol intake of 40 grams ethanol per day or more is associated with more rapid progression of liver disease associated with chronic HCV infection, including a more rapid increase in fibrosis and a doubled incidence of cirrhosis compared with patients with lower consumption levels (Wiley et al. 1998).
Additionally, there might exist an inherent iatrogenic risk of SLNB and SL in SLN-positive patients: As described by Thomas and Clark (2004), patients having SLNB have approximately double the incidence of local/in-transit recurrence, while SLN-positive patients having SL have greater than four times the expected incidence.
By 2050, the number of new cases is projected to be more than double the incidence in 2000 [ 2].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com