Sentence examples for double fork from inspiring English sources

The probability of a double fork stall increases as the square of the distance between two adjacent origins, so double fork stalls are proportionately more likely to occur between distantly spaced origins.

But for metazoans with much larger genome sizes than yeasts, the model predicts that double fork stalls become highly likely and might be expected to occur in ∼50% of all S phases in a typical human somatic cell.

Interestingly, this is about the size of the genomes of the five yeasts studied, and predicts that double fork stalls will be rare events that occur at a frequency similar to the natural chromosome loss rate.

In order to globally minimize large gaps and the probability of double fork stalls, it is also optimal to position replication origins at regularly spaced intervals across the genome.

The prediction that in somatic mammalian cells there is a high probability of the occurrence of double fork stalls suggests that these cells will have evolved mechanisms for effectively dealing with the consequences.

Indeed, previous work [75] had shown that deletion of five origins in S. cerevisiae, creating a large inter-origin distance of 160 kb (close to the expected value of the largest inter-origin distance if origins were randomly distributed), resulted in an increased chromosome loss rate exactly in line with the increased probability of double fork stalls [57].

It is possible that different nucleases act on single and double fork-stalled intermediates.

This shows that dormant origins can protect against double-fork stalls without the expense incurred by increasing the number of active replication forks.

The protection against double-fork stalling that is achieved by increasing the total number of licensed origins does not depend on whether these origins are efficient or whether they normally remain dormant [10].

This is probably because the maximum distance between adjacent origins in a cluster, where double-fork stalls are most likely to occur, is minimized if origins are evenly spaced.

The protection given by replication origins against double-fork stalls can also help to explain why eukaryotes generally use far more replication origins than are strictly required to complete replication in the time allotted for S phase.