Sentence examples for double deficient from inspiring English sources

Indeed, in Tet2/Tet3 double deficient mice, in which regulatory regions remain methylated, Foxp3 expression is unstable and Treg lose their suppressive functions (Yue et al., 2016).

These double deficient mice present severe clinical manifestations of muscular dystrophy [4], [5].

For comparision 14 tPA uPA double deficient mice were included, these were not given any antibody.

Furthermore, both Fsp27 deficient and Fsp27/leptin double deficient mice display improved insulin sensitivity and a lean phenotype.

Therefore, to further understand the in vivo functions of tankyrases, we have generated TANK1 knockout mice and TANK1/2 double deficient mice.

Relevant to cell death regulation, autophagy has been shown to be required for survival in Bax/Bak double deficient cells [29].

In contrast, TUNEL-positive cells at this region are significantly reduced in number in zTERT- and p53-double deficient embryos obtained via MO injections against the corresponding genes.

Bladders from rapamycin-treated Lkb1/Pten-double deficient mice showed negligible vimentin staining similar to the other three genotypes (Fig. 6, B).

Apoptosis levels were relatively unaffected, although notably apoptosis levels were already very substantial in the Pten/Lkb1-double deficient normal urothelium (Fig. S2).

These responses were absent in Gab1/2-double deficient mice, which exhibited high postnatal mortality and various signs of cardiac insufficiency.

Recently, a detailed analysis of HSC in an AKT1/2 double-deficient mouse model revealed a deficiency in competitive long-term reconstitution (Juntilla et al., 2010).