Sentence examples for double blockade from inspiring English sources

Recent work in a TP53−/− BRCA1-mutant murine breast cancer model indicates that double blockade with two immune checkpoint inhibitors increases the number of tumor-infiltrating lymphocytes and overall survival after DNA damaging chemotherapy, whereas single blockade does not.

Inhibition of either pathway decreased bone metastasis, with no further effect of double blockade.

Despite the double blockade, the time course of live organism shedding from the lower genital tract after C. muridarum infection was not significantly altered.

Marney et al. suggested that high levels of substance P, because of the double blockade of ACE and DPP-4, caused the activation of the sympathetic system.

A cross-sectional study design was used to compare the clinical manifestations of two WAD groups: 1) WAD participants who responded to cervical facet joint double blockade and subsequently proceeded to, and were awaiting RFN (WAD_Responders); 2) WAD participants who failed to respond to cervical facet joint double blockade (WAD_Non-Responders); and a 3) healthy control group (HC).

These studies found no difference in pCR rates between the trastuzumab and the lapatinib arms, although there was a statistically significant benefit of the double blockade when compared with the trastuzumab-alone regimen.

Simultaneous double-blockade of C5a receptors (C5aR or C5L2) dramatically improved survival from 0% to 70 80%, stressing the focal position of C5a during experimental sepsis.

Some of them, like double-blockade of the renin-angiotensin system (VA-nephron-D study, NCT00555217) or antibodies against tumor growth factor-β1 (NCT01113801), are still undergoing evaluation but their use will induce a higher risk of side effects, as suggested by the ONTARGET trial (35).

The approach employing simultaneous RAS blockade (AT1R) and RAS stimulation (AT2R) is distinct from previous attempts of double intervention in the RAS by dual blockade.

This dual blockade improves results.

However studies of double RAS blockade in high-risk patients have provided mixed results [ 25- 28] and current evidence therefore, does not support this therapeutic approach [ 29].