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Non-responders to an 8-week trial are switched double blind to either bupropion (for sertraline non-responders) or sertraline (for placebo non-responders) for an additional 8 weeks.
The 18 samples were assigned positive via specific diagnostic PCRs, but supplied to us double blind to ensure unbiased sequence analyses.
For ethical reasons in a population of children with confirmed GERD, this study did not include a placebo control group but was double blind to dosage.
After treatment, on day 3, children were subsequently randomised (double blind) to receive weekly chloroquine or placebo until day 90 (figure 1).
16 17 Given that vitamin D is available over the counter, trials had to be double blind to be included in the primary analysis.
After the run-in period and if still meeting the eligibility criteria, the patients were allocated double blind to a cycle of 4×once daily oral treatments in a random sequence.
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This study was single blinded because the physical forms of the products are sufficiently different for double blinding to be impractical.
Collected data regarding the groups were double blinded to the results of the serum PCT level.
However, it is not possible to achieve double blinding to intervention by a MET in a single-centre study.
The study was designed as a two-period crossover study with double blinding to the order of randomization to fish oil or placebo.
All study staff (investigators, pharmacists, members of the coordination centre and of the drug safety monitoring board, laboratory staff, statistician) were double blinded to treatment allocation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com