Immediate-release morphine was used as an escape analgesic during the second phase (double blind) of the study in order to get the information related to the morphine/oxycodone interaction.
NT and Hanada College possess the US patent 6575992B1, the Canadian patent CA 2339223, the Korean patent 0478177, the Taiwan patent 150135 and have registered the Chinese patent right (Title: Safe needle, placebo needle, and needle set for double blind) of the needles described in the manuscript.
When treatments differed in appearance or dosing double blinding of study treatments was maintained using the double dummy technique.
Our intention was to replicate that study with an adequate sample size, rigorous definitions of nipple damage and mastitis, and double blinding of the intervention.
Authors should also make every attempt to demonstrate: the purity of the supplement used; the double blinding of the treatments; and the reliability of the exercise tests or measure employed.
The strengths of this study are its randomised design and double blinding of the allocation to weekly CQ or placebo and that few subjects were lost to follow-up.
Only 4 studies used a control or placebo group to compare against intervention groups (4, 6, 7, 13), and of those, only 3 studies implemented double blinding of the intervention (4, 6, 7).
However, effective double blinding of such as study is difficult unless - as in a recent test in our laboratory - the subjects and the experimenter(s) conducting the study are made to believe that they participate in a full BPD.
Among the nineteen trials(Bentley_unpublished, –, –, –, – ) that were described as double blind, descriptions of blinding methods were provided in most.
Eftedal OS, Lydersen S, Helde G, White L, Brubakk AO, Stovner LJ (2004) A randomized, double blind study of the prophylactic effect of hyperbaric oxygen therapy on migraine.
In a double blind trial of undergraduate medical students, 3D models of cardiac anatomy resulted in higher test scores than cadaveric learning [13].
