Lithium or placebo was added on a double-blind basis for 6 weeks to the drug regime of 62 patients with major depressive illness (in both hospital and primary care settings) who had failed to respond to a controlled trial of fluoxetine or lofepramine.
Duloxetine or placebo was orally administered once daily after breakfast on a double-blind basis.
Patients were randomized to receive either 1 mg anastrozole (16 patients) or matching placebo (18 patients) once daily on a double-blind basis for 28 days.
For the purpose of validating self-reported use of street heroin by urine testing, a small group of participants were randomized to receive injectable hydromorphone in double-blind basis instead of diacetylmorphine.
Participants were randomly assigned at a ratio of 1 1 to 1000 μg of vaginal misoprostol or placebo, according to a randomised list of three permuted blocks on a double-blind basis at the outpatient consultation.
Thirty-one patients were randomized to self-administer finger pressure ("acupressure") at true or sham acupuncture points on a double-blind, crossover basis.
On the basis of these results, the phase III double blind, randomised, placebo controlled trial was started.
In addition, vaccine efficacy in a double blind, randomised and placebo controlled trial was judged to be statistically evaluable on the basis of previous findings.
