Sentence examples for double alterations from inspiring English sources

Even though the performance in finding the fully correct network became poor, the linkages in the correct network were generally properly identified with high frequency, again indicating that the cases where the network was incorrect generally involved single or double alterations in the pathways of the network.

Considering that the cell lines used in this study differ in several molecular and biological characteristics like genetic alterations, doubling time, morphology and motility, our results may suggest that diminished FOXP1 expression might act as a growth-promoting factor in neuroblastoma in general.

In other words the effect of CAT-354 on the double allergen challenge induced alterations in model phenotype on a per-animal basis.

These act7;aip1-2 double mutants displayed striking alterations of shoot architecture, such as twisted stems and siliques abnormally oriented along the shoot, when compared with the single mutants (Fig. 3D-G; supplementary material Fig. S3B-F).

The hha/ydgT double inactivation showed transcriptional alterations in a similar number of genes, with 134 genes up-regulated and 5 genes down-regulated (Fig.  1F and Supplementary Table S6).

The hns/stpA double mutant showed further alterations in the transcriptome profile, with up-regulation of 583 genes, 167 of which were included in the 172 genes up-regulated in the hns single mutant, and down-regulation of 86 genes compared with wild-type (Fig.  1C and Supplementary Table S4).

Here, we report the design and characterization of a double-mutant p53 with alterations of residues at positions Met340 and Leu344.

The reduction-of-function allele e1370 induces several metabolic alterations and doubles lifespan.

Double-hit RAS-pathway alterations were confirmed in six additional MC cases (total 21.6 %).

As a protein complex that regulates the assembly and organization of both interphase and mitotic microtubules, it is not surprising that Nde1 Lis1 double deficiency caused significant alteration of radial glial morphology besides mitotic defects.

Characterisation of these lines has revealed that both are highly aneuploid containing multiple clonal chromosome alterations, have doubling times near 100 h, and are oestrogen and progesterone receptor negative.