This causes several problems, including compatibility when multi booting with operating systems that set the clock to UTC, and double-adjusting the clock when multi booting different Windows versions, such as with a rescue boot disk.
The risk of de novo CKD was nearly doubled (adjusted HR 1.9; 95% CI 1.75 2.09).
The nation's manufacturing output has more than doubled since 1970, adjusting for inflation.
In research that Carmen Reinhart and I have done on the history of financial crises, we find that public debt typically doubles, even adjusting for inflation, in the three years following a crisis.
Yet the time spent to develop a drug, not counting the months consumed by government review, has lengthened to more than 11 years from about 9 years in the 1980's, according to the Tufts Center for the Study of Drug Development, and the cost has more than doubled, after adjusting for inflation, to $800 million.
Between 1993 and 2012, the share of American graduates taking out student loans rose by 25 percentage points and average debt per borrower doubled, after adjusting for inflation.That is worrying, in that investment in higher education, though lucrative on average, yields highly variable returns.
As he noted in a hearing last week, NIH's budget has grown in that time from $1.8 billion in 1973 to $31 billion in 2010 almost a doubling after adjusting for inflation.
Current total annual funding for biomedical research in the U.S. is approximately $100 billion, and over the past decade has tripled in nominal dollars and doubled after adjusting for inflation [1], [2].
The risk of painful neuropathy symptoms in type 2 diabetic patients was 83% higher than in type 1 patients (OR = 1.8 [95% CI 1.6 2.1], P < 0.0001); this risk doubled after adjusting for differences in age and diabetes duration (OR = 2.1 [1.7–2.4], P < 0.0001).
"It brings together two uniquely complementary assets, gives Shutterfly access to more than 10 million highly desirable households and, as a result, we expect to almost double our adjusted EBITDA by 2020," said Shutterfly chief executive Christopher North, on yesterday's earnings call.
"It's weird when my mom starts talking about double clutching and adjusting the carburetor," Jay Fisher says.
