A comparison between France and Germany is difficult, due to discrepancies between submitted dossiers regarding drug substance and applied indirect comparisons, which mostly differ in each country.
During public consultation regarding the restriction dossier (see Fig. 1), more than 600 comments were received by ECHA, much more than in all former restriction processes (see Table 1).
Potential expert contributors submit resumes or CVs along with a letter of interest and may be given curatorial levels of access, while members of the general public will not have the ability to edit or add citations but may submit comments or proposals regarding dossier content that the curators or project leaders can take into consideration.
"We have not uncovered a single document that would in any way corroborate the dossier's allegations regarding Mr. Cohen, nor do we believe that any such document exists," the letter to the House Intelligence committee reads, according the New York Times, which obtained a copy.
These prices are set only to recover costs and may change depending on the costs incurred for the harvest of the tissues.> Tissue samples are accompanied by a dossier of information regarding the mouse's pedigree, rearing and method of sacrifice (Table 1).
The manufacturers' dossiers were reviewed regarding their respective claims.
Cardiff submitted a dossier to the FA regarding the alleged misconduct of Mackay, their former manager, and Moody, the former head of recruitment.
When Spyros Skouras, then head of Fox, arrived in London, he was presented, Wanger reports, "with a dossier compiled by his experts regarding the production, including a sheaf of weather reports on England for the past three years which indicated why the picture shouldn't be made here".
The underlying methodology of an indirect comparison which is used in a benefit dossier has to be consistent (regarding comparability of effects) and must be described very accurately to allow a reproduction of the procedure by IQWiG and G-BA [7],[15].
