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In combination with CsA, FTY720 was well tolerated following single or multiple dosing, without any evidence of additional toxicities, indicating that FTY720 may be useful in the future design of more effective and less toxic regimens for prevention of graft rejection.
Dose escalation was stopped at 1500 mg BID continuous dosing without reaching the MTD of telatinib.
Thus, it is desirable to reduce the frequency of alendronate dosing without compromising treatment efficacy.
The use of meta-analyses to titrate dosing without any measurements of admission glutamine status or post-treatment glutamine status is not good science.
Efforts targeted a half-life suitable for once- (qd) or twice-daily (bid) dosing, without large differences in peak and trough concentrations.
Low-molecular-weight heparins have more predictable pharmacokinetics and greater bioavailability, which permits body-weight-adjusted dosing without the need for laboratory monitoring for most patients.
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One can take it in heavy doses without any undesired effects.
"Ed knew there was no such thing as a dose without risk".
Q.: How do doctors go about figuring out a dose without adequate information?
As the cancer advances, Abdulaziz will presumably need more — some patients take 15 times his dose without even getting drowsy.
Using more potent and selective progestins allows for lower estrogen doses without disrupting a woman's menstrual cycle.
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CEO of Professional Science Editing for Scientists @ prosciediting.com