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Serum conbercept concentrations after IVT dosing were low and bioavailability was approximately 44%.
Moreover, no significant differences between discrete dosing and cassette dosing were observed.
The pharmacokinetic parameters of the drug post intravenous dosing were reported for the first time.
Three patients were said to respond to a trial of amitriptyline but no details of dosing were given [9].
Additional hourly blood samples from 1 to 6 h after oral lapatinib dosing were assessed on the day 8 scan.
Control urine samples obtained from rats prior to drug dosing were prepared in the exact way described for each method of sample purification.
Control urine samples obtained from rats prior to drug dosing were prepared in a similar way to the above mentioned method.
Serial blood samples (0.3 mL; 0, 5, 15, 30 min and 1, 2, 4, 6, 8, 10 and 24 h post dosing) were collected into heparinized tubes.
Simulations for oral dosing were performed using the 30-mg/kg oral dose in order to assess the dose frequency required to hit a range of target concentrations.
The results indicated that the plasma drug concentrations versus time curves after intravenous injection of five antagonists via cassette dosing were all fitted to a two-compartment model.
Liver GSH stores 1 2 h after dosing were unaffected, suggesting that GSH depletion is not likely a relevant mode of action in the liver.
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