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Fixed dosing was evaluated using doses of 35, 70, 140, 210, and 315 mg which correspond to 0.5, 1, 2, 3, and 4.5 mg/kg dosing for a 70 kg subject.
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Each RG3487 dose was evaluated using a mixed-effects model repeated measures approach.
For each patient, effective dose was evaluated using standard coefficients referring to a generic reference individual.
Following the recommendations of Publication 103 of the ICRP [14], these absorbed doses were then sex-averaged and the effective dose was evaluated using the tissue weighting factors of Publication 60 of the ICRP [15].
The association between the actual and calculated phenprocoumon doses was evaluated using Passing Bablok regression analysis.
The relationship between projection-based dose metric and MC dose estimate was evaluated using regression models.
The pharmacokinetic dose proportionality was evaluated using a power model with Cmax and the AUC for the dosing period (AUCτ) for luseogliflozin on Day 7. Pharmacodynamic variables included 24-h cumulative UGE, total UGE, and UGE rate in each collection period.
Dose response was evaluated using contrasts within the ANCOVA model framework.
Dose response western data was evaluated using a one-way ANOVA followed by a Dunnet's post-hoc test.
The dose of dialysis delivered was evaluated using a second-generation Kt/V equation by Daugirdas [ 16].
Dose dependency of OO extract was evaluated using further dilutions (1 10 and 1 100) in RPMI medium.
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