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Dosing was done between 2 and 3 PM.
In the SR phase, dosing was done twice each day at 1000 and 2200.
Drug dosing was done i.p. formulated in a DMSO and PBS mixture, and p.o. formulated in a DMSO, water and peanut butter mixture.
This escalation in dosing was done at increments of 75 mg/day or 1.5 mg/kg/day for patients weighing ≤40 kg to a maximum of 200 mg/day per the European protocol.
During 7-days of the treatment period, modification in the analgesic dosing was done for 29 and 38%% of the patients in the rotation group and combination group, respectively (p = 0.49).
Dosing was done in a fasting state with the subjects in supine position with the upper half of the body semi-elevated, and at the same time in the morning for all treatments.
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Most dosing is done orally and formulation possibilities include powder in a capsule, powder and excipient in a capsule, or liquid formulations (solutions or suspensions).
Adjustment to her lithium dose was done to maintain levels at 0.6 to 0.8 mmol/L.
The dichotomization of BMI, HbA1c and insulin dose was done since these patient characteristics have been proposed as markers of insulin resistance a suggested target of metformin treatment.
The selection of the appropriate thioridazine dose was done following previous publications [11]; we tested 16, 32 and 70 mg/kg dosages.
Scheduling of doses was done at the point of prescribing.
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