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Carboplatin AUC dosing was calculated using the Calvert formula 10.
For those who had received carboplatin chemotherapy the dosing was calculated using the Calvert formula (Calvert et al, 1989) (Table 1).
The area under the concentration versus time curve (AUC) from time 0 to 24 hours (AUC0 24) after dosing was calculated using the linear-log trapezoidal rule.
According to clinical studies, approximately 16% of patients using manually coded blood glucose meters miscode them, 10 and the probability of incorrect insulin dosing was calculated using this value.
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The effective dose was calculated using the International Commission on Radiological Protection 103 recommendations.
The percentage increase of effective dose was calculated using the weighting factors in ICRP 103 (see Table 2).
Effective dose was calculated using the two sets of tissue weighting factors given in ICRP Publications 60 and 103.
The initial dose was calculated using the infant's weight at the start of prophylaxis as reported in the RCTs [16, 17].
The initial dose was calculated using the infants' average weight at the start of prophylaxis as reported in the pivotal trial (6.1 kg).
The effective dose was calculated using the tissue weighting factors from ICRP Publication 103 as 0.016 mSv/MBq (4.7 mSv for an administration of 290 MBq).
The effective dose was calculated using the new tissue weighting factors from ICRP publications 103 and the prior factors from ICRP publication 60.
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