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As innovative as biologic-device combination products are, they can pose considerable development, regulatory, and commercialization challenges due to unique physicochemical properties and special clinical considerations (e.g., dosing volumes, frequency, co-medications, etc). of the biologic medicine.
The dosing volumes of diuretics were adjusted to 1 ml.
We recorded body weights daily and adjusted dosing volumes daily.
Reports of longer times to onset after acute exposures (e.g., Soderlund et al. 2002) have been attributed to larger dosing volumes that delay absorption (Kim et al. 2007; Wolansky et al. 2007).
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Subsequently, radiobiological modeling is performed on a per-voxel basis and cumulative dose volume histograms (DVHs) are generated.
Dosing volume was 1 mL/kg.
The dosing volume was 500 mg/kg.
The dosing volume was 5 mL/kg body weight.
The dosing volume was 2 mL/kg body weight; the dosing vehicle was deionized water.
Dosing volume was 5 ml/kg and was adjusted weekly based on body weight measurements.
Rabbits were reweighed on Day 6 and dosing volume was adjusted accordingly.
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