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Our results also indicate that the body surface area-based dosing used in pediatric trials can make a difference in dose escalation/de-escalation patterns in the CRM compared to the cases where such variations are not taken into account in the calculations, even leading to different MTDs in some cases.
This suggests that the infliximab group may have included a higher proportion of AS patients, which could have magnified between-group cost differences due to the dosing used for infliximab in AS patients.
[7], [8] The elevated plasma concentrations found in our study reflect in part the higher dosing used in our patients.
The IC50 values obtained for stavudine, lamivudine, and zidovudine in this study are achieved by standard dosing used in the treatment of HIV-1.
For moxifloxacin the 100 mg/kg dosing used in mice generates an AUC equivalent to the lowest AUC that can be achieved in patients and that is about 50% the highest AUC that can be achieved in patients [23], [24], [25].
This corresponds to the dosing used in the clinical study [ 2].
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dosing using the i.v. preparation in sterile prefilled syringes.
But he said the individual doses used in Denmark were larger.
In the lower doses used to treat leishmaniasis, side effects have not been severe.
The 10mL dose, used by postmenopausal women, has not been affected.
The American Academy of Anti-Aging Medicine said in a statement that the doses used in the study were far too high.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com