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GH dosing titrated to an IGF-I target of 0 SDS was the most dose-sparing treatment regimen for GHD or ISS children (mean±SE ΔHSDS/GH dose ratios 48·1 ± 4·4 and 32·5 ± 2·8, respectively) compared with conventional dosing (30·3 ± 6·6 and 21·3 ± 3·5, respectively; P = 0·02, P = 0·005) and IGF2T (32·7 ± 4·8 and 16·3 ± 2·8, respectively; P = 0·02, P < 0·0001).
27 However, individual dosing titrated to effect makes this population comparison between younger and older patients less clinically meaningful.
Conventional weight-based dosing of GH (0·04 mg/kg/day) (n = 34) or GH dosing titrated to an IGF-I target of 0 SDS (IGF0T; n = 70) or an IGF-I target of +2 SDS (IGF2T; n = 68).
Similar(57)
Careful initial opiate dose adjustment should be made in the setting of these interactions, patients monitored closely, and doses titrated accordingly.
Apremilast was dose-titrated over the first week of treatment (10 mg on the first day, with increases of 10 mg/day until the target dose was reached).
30 Liraglutide-placebo (Victoza, Novo Nordisk A/S, Bagsvaerd, Denmark) was packaged, administered and dose-titrated in an identical manner to the liraglutide comparator, described above.
Aiming for a more modest and intermediate pH target with bicarbonate dose less than half of that predicted, or dose titrated based on pH severity, were some of the variable approaches adopted subsequently by investigators [4, 23].
32 The majority of patients had their doses titrated up, but 14% responded sufficiently to be able to have their dose titrated down to the lowest dose.
metformin (dose titrated up over 4 weeks starting at 500 mg b.i.d).
No patients had their drug dose titrated and it was assumed that there was no vial wastage in drug usage.
Midazolam is administered by continuous intravenous infusion in critically ill neonates and the dose titrated according to the response.
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