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The ranges of dosing timings that induce the stable entrainment become narrower as day length increases.
To extend our experimental results to different LD cycles or different dosing timings, we used an accurate and detailed mathematical model of the intracellular mammalian circadian clock, which accurately predicts many phenotypes of circadian mutations including the tau mutation in CK1ε.
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With an accurate and detailed mathematical model of mammalian circadian clock, we studied how dosing amount, dosing timing, and day length affect the chronic dosing-induced phase delay.
Food drug interaction studies are critical to evaluate appropriate dosing, timing, and formulation of new drug candidates.
The adherence index was based on questions from the follow-up questionnaire covering dosing, timing and special instructions (Table 1, Appendix S1).
More than one third of patients were non-adherent when all three aspects of adherence – dosing, timing and special instructions – were taken into account.
Two different adherence measures were used: (1) "dose adherence" (the proportion of a prescribed dose taken over the past 4 days) and (2) "adherence index" (based on three adherence questions covering dosing, timing and special instructions).
In addition to dosing, timing, membranes and fluids, the mode of CRRT varies.
These studies highlight again the importance of PDGF dosing, timing, and delivery methods.
These questions include dosing, timing, and the route and duration of administration.
In fact, the variability in dosing timing often prevented entrainment from occurring at ZT11.
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CEO of Professional Science Editing for Scientists @ prosciediting.com