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After completing the simulated injection scenarios in both validation studies, participants were asked for a subjective assessment of the IFU's directions on the 10 critical dosing steps.
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Forearm blood flow (FBF) was measured during the final 2 min of each dosing step in both arms, using ECG-triggered mercury-in-silastic strain gauge venous occlusion plethysmography as described previously [ 25].
Such information would be useful for "dosing" daily steps in clinical practice.
No other episodes of DLT were observed at the same dose steps and at the lower dose steps of capecitabine (1,500/1,750/2,000/2,250/2,500 mg/m).
The genuine and the modified Fibonacci sequence determine dose steps (increments).
Titration was allowed in dose steps of 600 IU up to a maximum dose of 6,000 IU.
He starts with 10 dose steps (units of measure for this fixed combination) and titrates every week.
During the first 9 days, the assigned antipsychotic is uptitrated in fixed dose steps, with slower titrations and dose adjustments if clinically indicated (see below).
This demonstrates that relatively large dose steps are clinically necessary early post-transplantation, while the genotype effects appear to be small.
Titration of lisdexamfetamine is similar to that of methylphenidate, but with three rather than four dose steps (30, 50 and 70 mg).
He is empowered with the up-titration algorithm (decrease dose by two dose steps if fasting plasma glucose [FPG] <72 mg/dL [4 mmol/L], no change in dose if FPG 72 90 mg/dL [4 5 mmol/L], increase dose by two dose steps if FPG >90 mg/dL [5 mmol/L]).
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