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Consequently, pediatric pharmacokinetic (PK) and pharmacodynamic (PD) studies are needed to inform dosing selection for efficacy trials and for establishing dosing recommendations for pediatric subpopulations.
Formulation preparation and dosing selection are often more challenging in children.
Dosing selection generally requires the models to extrapolate across different dosing frequencies and administrative routes.
The model provides direct insight into NO metabolome disposition and is valuable for nitrite dosing selection in clinical trials.
Tools from information technology and progress in microbiology will reduce diagnostic uncertainty and improve antimicrobial dosing, selection, and treatment duration.
Also, dosage adjustment was commonly ignored by physicians, suggesting that the severity of inappropriate drug and dosing selection might be underestimated [ 36, 37].
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Concentrations used in the exposure experiments were pre-selected in the dose selection experiments (cytotoxicity analysis).
Sponsors have used different MABEL approaches for FIH dose selection.
Our results provide additional data for rational dose selection of intrathecal clonidine.
The strategy consisted of three stages: quantification, reagent dose selection and robustness analysis.
Issues related to clinical trials of molecularly targeted agents are discussed, including patient and dose selection.
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