Not surprisingly, the two companies argue over which dosing scheme is better.
This can have significant consequences on study design (both pre-clinical and clinical), in particular on dose selection, dosing scheme, and sampling times.
Nonlinear PK caused by TMDD may have significant consequences on study design (both pre-clinical and clinical), in particular on dose selection, dosing scheme, and sampling times (Dirks & Meibohm, 2010; Grimm, 2009).
The design of the cosyntropin dosing scheme was inspired by previous reports [ 9, 10].
Additional studies are needed to determine the optimal danaparoid dosing scheme during CVVH with an ultrafiltration rate of 35 mL/kg per hour or more.
ETR was given once daily in this study, as opposed to the currently approved twice-daily dosing scheme, and appeared to retain good activity.
The decision rule for reported praziquantel dosing scheme coverage over the previous year was only met in Changan Kul where 23 dogs were reportedly dosed in the last year.
As occurs with many members of this pleiotropic family of ligands, slight differences in dosing scheme, duration of treatment, cell type and context can impact the results of the study.
Factors such as the drug mechanism of action and the time frame of PD response, as it relates to the driver and dosing scheme, should be considered when assessing drivers of PD response.
The use of this combination and dosing scheme in the recurrent setting is probably not feasible at this time, due to the near universal exposure of GBM patients to TMZ as an up-front treatment.
Responders were administered the recommended initial doses of ESAs for the total of 15 weeks, while non responders' dosing scheme was escalated to 200% of the initial dose in the beginning of the week 9 until the end of 15th week.
