Sentence examples for dosing schema from inspiring English sources

However, if a lower daily dosing schema (225 mg day−1) is selected, the mean plasma concentration decreases to 160 ng ml−1 (0.36  μ M) (Baselga et al, 2002).

This reduced dose schema of 5 mg/m intravenously on days 1, 3, 6 and 11 was originally developed specifically to decrease the risk of mucosal and hepatic complications, and has been widely used in combination with cyclosporine or tacrolimus as GVHD prophylaxis with historically similar outcomes as standard doses.

The planned dose escalation schema (Table S1); for doses greater than 200 mg, HCQ was administered in divided, twice-daily doses, taken approximately 12 h apart.

The planned dose escalation schema is as per Table S1: HCQ daily dose cohorts: 1) 200 mg, 2) 400 mg, 3) 800 mg, and 4) 1200 mg.

In a subsequent phase 2 study in previously treated patients with HCC and Child-Pugh A cirrhosis, the tivantinib dose was reduced to 240 mg BID and a modified dose-reduction schema was implemented because of grade 3 or greater neutropaenia (Santoro et al, 2012).

The results suggest that MTD is usually not well defined with a cohort of 3 6 patients in the traditional dose escalation schema.

Twenty patients with R/R B-ALL and one patient with diffuse large B cell lymphoma (DLBCL) were treated; the maximum tolerated dose (MTD) for the entire cohort was defined as 1 × 106 CAR-T cells/kg by using a 3 + 3 dose-escalation schema.

Dose reduction schema for nab-paclitaxel and S-1.

Dose escalation schema: Three patients were planned to be entered into each DL.

Three patients were planned to be entered into each DL and the dose escalation/expansion schema was standard.

Since we had decided to include in our trial anthracycline- and taxane-pretreated patients, we planned a dose reduction schema for haematologic toxicity for paclitaxel.