These regimens abrogate oral dosing requirements, but require periodic visits to a physician's office or infusion center for administration.
(Phase II trials aim at determining dosing requirements and demonstrating therapeutic efficacy; Phase III trials are on a larger scale and usually compare a drug's results with standard treatments).
We evaluated the dosing requirements in argatroban-treated patients with heparin-induced thrombocytopenia (HIT) and hepatic dysfunction, and compared efficacy and safety outcomes with historical control patients.
Similarly, the lack of data on the impact of obesity on dosing requirements forces the clinician to base dosing on actual body weight to ensure achievement of desired drug concentrations.
Due to the lack of published literature on the effects of critical illness and treatment on the pharmacokinetics of TMP/SMX, the clinician must attempt to estimate dosing requirements.
However, this modeling showed the effect to be 5-10 timesmallerer in ICU patients, to be highly patient-specific depending on patient status, and to (overall) have very little impact on TGC dosing requirements, as a result.
These factors can potentially affect the safety and dosing requirements in vaccine and other biomedical prevention technology trials and yet prevention and treatment recommendations for young people are often extrapolated from the results of adult-only studies.
Thyroid activity also appears to influence warfarin dosing requirements; hypothyroidism (decreased thyroid function) makes people less responsive to warfarin treatment, while hyperthyroidism (overactive thyroid) boosts the anticoagulant effect.
In this study, DP is clearly superior to AL at preventing new malaria infections; is at least as safe as AL; and with simpler dosing requirements and lower cost, it appears to be a preferable alternative.
Measured subject's weight was used to estimate the isotope dosing requirements.
Reducing the turnaround time would mean less time for pathophysiological alterations to change the dosing requirements.
