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Complete dosing records and patient variables (demographic, prognostic, and biochemical factors) were collected.
In the simulation-based model evaluation, dosing records were imputed according to protocol until the time of the last observed tumor assessments in each substudy (see Supplementary Data).
These dosing records were deemed sufficient to characterize the pharmacokinetics of levodopa since levodopa has a very short half-life (less than 2 h).
Dosing records included the amounts, dosing times, rates of infusion and infusion duration (when applicable, doses associated with tube flush were considered bolus).
Dosing records on the pharmacokinetic sampling days and the days immediately preceding pharmacokinetic sampling days were included in the analysis dataset.
Simulations using the original dosing records are usually inappropriate in this setting because the simulation scenarios often contain much higher and lower responses than those observed with the index data, producing prediction intervals that are inflated and potentially biased.
Similar(51)
Compliance was assessed by regular reviews of investigational product administration data including dosing recorded on case report forms, the investigational product accountability records and source documents reflecting patient's medical care.
We present here a particular application area for EPR dosimetry with teeth use as a source of reference dose values for validation/verification of other retrospective dosimetry techniques and existing dose records.
The study population contains persons occupationally exposed to ionising radiation and for whom radiation dose records were kept.
The facility's Radiation Safety section or Medical Physics Service should review the personal dose records of individual workers regularly.
The first reactor at AECL came on line in 1949 but a fire destroyed AECL dose records in 1955.
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